A role for heterodimerization in nuclear localization of a homeodomain protein.

@article{Spit1998ARF,
  title={A role for heterodimerization in nuclear localization of a homeodomain protein.},
  author={A F Spit and Robert H. Hyland and E J Mellor and Lorna Ann Casselton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 11},
  pages={6228-33}
}
The A mating type genes of the mushroom Coprinus cinereus encode two families of dissimilar homeodomain proteins (HD1 and HD2). The proteins heterodimerize when mating cells fuse to generate a transcriptional regulator that promotes expression of genes required for early steps in sexual development. In previous work we showed that heterodimerization brings together different functional domains of the HD1 and HD2 proteins; a potential activation domain at the C terminus of the HD1 protein and an… CONTINUE READING