A role for hepatitis C virus infection in type II cryoglobulinemia.

  title={A role for hepatitis C virus infection in type II cryoglobulinemia.},
  author={Vincent Agnello and Raymond Tsang Chi Chung and Lee M. Kaplan},
  journal={The New England journal of medicine},
  volume={327 21},
BACKGROUND Type II cryoglobulinemia is a vasculitis characterized by cryoglobulins consisting of complexes of polyclonal IgG and monoclonal IgM rheumatoid factors. The cause of these immune complexes is unknown, though both the hepatitis B (HBV) and C (HCV) viruses have been suspected. METHODS We studied 19 patients with Type II cryoglobulinemia for markers of HCV and HBV infection. Quantitative HCV antibody and RNA studies were performed on whole serum, cryoprecipitates, and supernatants… CONTINUE READING
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