A role for glucagon-like peptide-1 in the central regulation of feeding

  title={A role for glucagon-like peptide-1 in the central regulation of feeding},
  author={Mandy D Turton and Donal O'Shea and Irene Gunn and S. A. Beak and C. Mark B. Edwards and Karim Meeran and Suck Jun Choi and Gillian M Taylor and Melanie M. Heath and Philip D. Lambert and John P H Wilding and Davey M. Smith and Mohammad A. Ghatei and J C Herbert and Stephen R. Bloom},
THE sequence of glucagon-like peptide-1 (7–36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role1. We have shown that GLP-1 and its specific receptors are present in the hypo-thalamus2,3. No physiological role for central GLP-1 has been established. We report here that intracerebroventricular (ICV) GLP-1 powerfully inhibits feeding in fasted rats. ICV injection of the specific GLP-1-receptor antagonist, exendin (9-39)4… CONTINUE READING
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