A role for genomic instability in cellular radioresistance?

  title={A role for genomic instability in cellular radioresistance?},
  author={William F. Morgan and John P. Murnane},
  journal={Cancer and Metastasis Reviews},
Inherent cellular radioresistance plays a critical role in the failure of radiotherapy. Although the consequences of radioresistance are well known, the molecular, biological, and cellular bases of radioresistance remain a mystery. We propose that genomic instability, the increased rate of acquisition of alterations in the mammalian genome, can directly modulate cells' sensitivity to radiation. In particular, destabilization of chromosomes occurring as a consequence of genomic instability may… CONTINUE READING

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Radiobiology for the Radiologist

  • EJ Hall
  • J.B. Lippincott Co., Philadelphia
  • 1994

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