A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.

@article{Robinson2000ARF,
  title={A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.},
  author={Lisa Annette Robinson and Chandra Nataraj and David W. Thomas and David N. Howell and Robert C. Griffiths and Victoria L Bautch and Dhavalkumar D. Patel and Lili Feng and Thomas M. Coffman},
  journal={Journal of immunology},
  year={2000},
  volume={165 11},
  pages={6067-72}
}
The hallmark of acute allograft rejection is infiltration of the inflamed graft by circulating leukocytes. We studied the role of fractalkine (FKN) and its receptor, CX(3)CR1, in allograft rejection. FKN expression was negligible in nonrejecting cardiac isografts but was significantly enhanced in rejecting allografts. At early time points, FKN expression was particularly prominent on vascular tissues and endothelium. As rejection progressed, FKN expression was further increased, with prominent… CONTINUE READING