A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.

@article{Cheng2010ARF,
  title={A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.},
  author={Qiufang Cheng and Erik I. Tucker and Meghann S Pine and India Sisler and Anton G Matafonov and Mao-fu Sun and Tara C White-Adams and Stephanie A. M. Smith and Stephen R. Hanson and Owen J. T. McCarty and Thomas Renn{\'e} and Andr{\'a}s Gruber and David Gailani},
  journal={Blood},
  year={2010},
  volume={116 19},
  pages={3981-9}
}
Mice lacking factor XII (fXII) or factor XI (fXI) are resistant to experimentally-induced thrombosis, suggesting fXIIa activation of fXI contributes to thrombus formation in vivo. It is not clear whether this reaction has relevance for thrombosis in pri mates. In 2 carotid artery injury models (FeCl(3) and Rose Bengal/laser), fXII-deficient mice are more resistant to thrombosis than fXI- or factor IX (fIX)-deficient mice, raising the possibility that fXII and fXI function in distinct pathways… CONTINUE READING