A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors.

@article{Paternain2003ARF,
  title={A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors.},
  author={Ana V. Paternain and Adir Cohen and Yael Stern-Bach and Juan Lerma},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 25},
  pages={8641-8}
}
Ionotropic glutamate receptors of the kainate and AMPA subtypes share a number of structural features, both topographical and in terms of stoichiometry. In addition, AMPA and kainate receptors share similar pharmacological and biophysical properties in that they are activated by common agonists and display rapid activation and desensitization characteristics. However, we show here that in contrast to AMPA receptor-mediated responses (native or recombinant GluR3 receptor), the response of native… CONTINUE READING

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Ion-dependent gating of kainate receptors.

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