A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke.

@article{Overman2012ARF,
  title={A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke.},
  author={Justine J Overman and Andrew N. Clarkson and Ina B Wanner and William T Overman and Ilya Eckstein and Jaime L Maguire and Ivo D. Dinov and Arthur W. Toga and S Thomas Carmichael},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 33},
  pages={E2230-9}
}
Stroke causes loss of neurological function. Recovery after stroke is facilitated by forced use of the affected limb and is associated with sprouting of new connections, a process that is sharply confined in the adult brain. We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke. Blockade of ephrin-A5 signaling using a unique tissue delivery system induces the formation of a new pattern of axonal… CONTINUE READING