A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics.

@article{McRae1981ARF,
  title={A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics.},
  author={John R. McRae and Stewart A. Metz and Ronald P. Robertson},
  journal={Metabolism: clinical and experimental},
  year={1981},
  volume={30 11},
  pages={
          1065-75
        }
}
Noninsulin dependent diabetics have insulin responses to nonglucose secretagogues that are subnormal for their plasma glucose levels. Since endogenous prostaglandins have been implicated in the abnormal insulin responses to glucose in diabetics, the present study was performed to explore whether prostaglandins might also play a role in the defective insulin responses to nonglucose stimuli. We examined the effects of infusions of either prostaglandin E2 (PGE2) or sodium salicylate (SS), a PG… CONTINUE READING