A role for endogenous mono-hydroxy-eicosatetraenoic acids (HETEs) in the regulation of human neutrophil migration.


The possibility that endogenous monohydroxy-eicosatetraenoic acids (HETEs) derived from the lipoxygenation of arachidonic acid might serve a role in human neutrophil migration was examined by studying the effects of depletion of the intracellular HETEs on random migration and chemotaxis. The intracellular contents of approximately 2000 ng of 11-HETE and 500… (More)


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