A role for elongator in zygotic paternal genome demethylation

  title={A role for elongator in zygotic paternal genome demethylation},
  author={Yuki Okada and Kazuo Yamagata and Kwonho Hong and Teruhiko Wakayama and Yi Zhang},
The life cycle of mammals begins when a sperm enters an egg. Immediately after fertilization, both the maternal and paternal genomes undergo dramatic reprogramming to prepare for the transition from germ cell to somatic cell transcription programs. One of the molecular events that takes place during this transition is the demethylation of the paternal genome. Despite extensive efforts, the factors responsible for paternal DNA demethylation have not been identified. To search for such factors… CONTINUE READING