A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells.

@article{Muschler2002ARF,
  title={A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells.},
  author={John Muschler and Dinah D. Levy and Roseanne Boudreau and Michael Henry and Kevin Campbell and Mina J. Bissell},
  journal={Cancer research},
  year={2002},
  volume={62 23},
  pages={7102-9}
}
Receptors mediating cell-basement membrane interactions are potent regulators of epithelial architecture and function, and alterations in signals from the basement membrane are implicated in the aberrant behavior of carcinoma cells. In this study, we have investigated the role of the basement membrane receptor dystroglycan (DG) in mammary epithelial cell function, and the significance of loss of DG function in breast tumor cell lines. Nonmalignant mammary epithelial cells express a functional… CONTINUE READING
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