A role for corticotropin-releasing factor in the long-term expression of behavioral sensitization to cocaine.

@article{Erb2006ARF,
  title={A role for corticotropin-releasing factor in the long-term expression of behavioral sensitization to cocaine.},
  author={Suzanne Erb and Zenya J. Brown},
  journal={Behavioural brain research},
  year={2006},
  volume={172 2},
  pages={360-4}
}
Corticotropin-releasing factor (CRF) has been implicated in a number of the behavioral and biochemical effects of cocaine. We recently reported that central injections of CRF produce a potentiated locomotor response in animals that had been given repeated injections of cocaine up to 4 weeks earlier. We now report that with as few as 1 or 3 exposures to cocaine (total of 45 mg/kg, i.p., per day), and a drug-free period of 28 days, i.c.v. injections of CRF (0.5 microg) produce augmented locomotor… CONTINUE READING

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