A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection.

@article{Anand2008ARF,
  title={A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection.},
  author={Rahul J. Anand and Shipan Dai and Steven C. Gribar and Ward M. Richardson and Jeff W. Kohler and Rosemary Hoffman and Maria F. Branca and Jun Li and Xiao-hua Shi and Chhinder P. Sodhi and David J. Hackam},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={8534-8543}
}
The pathways that lead to the internalization of pathogens via phagocytosis remain incompletely understood. We now demonstrate a previously unrecognized role for the gap junction protein connexin43 (Cx43) in the regulation of phagocytosis by macrophages and in the host response to bacterial infection of the peritoneal cavity. Primary and cultured macrophages were found to express Cx43, which localized to the phagosome upon the internalization of IgG-opsonized particles. The inhibition of Cx43… CONTINUE READING
Highly Cited
This paper has 116 citations. REVIEW CITATIONS

Topics

Statistics

02040602012201320142015201620172018
Citations per Year

117 Citations

Semantic Scholar estimates that this publication has 117 citations based on the available data.

See our FAQ for additional information.