• Biology, Medicine
• Published in
  The Journal of neuroscience…
  2000
• DOI:10.1523/JNEUROSCI.20-09-03415.2000

A role for complement in the rejection of porcine ventral mesencephalic xenografts in a rat model of Parkinson's disease.

@article{Barker2000ARF,
  title={A role for complement in the rejection of porcine ventral mesencephalic xenografts in a rat model of Parkinson's disease.},
  author={Roger A. Barker and Elyanne M. Ratcliffe and Margaret M. McLaughlin and Andrew L. Richards and Stephen B. Dunnett},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 9},
  pages={
          3415-24
        }
}

• Roger A. Barker, Elyanne M. Ratcliffe, +2 authors Stephen B. Dunnett

Vascularized whole organ discordant xenografts placed in the periphery are rejected by a rapid "hyperacute" process that involves preformed antibody binding to the xeno-antigens on the donor endothelial cells with complement activation. In the CNS, xenografts are classically thought to be rejected more slowly by a T-cell-dependent process. We now report that xenografts of embryonic porcine ventral mesencephalic tissue in the 6-hydroxydopamine-lesioned, nonimmunosuppressed rat induce both a… CONTINUE READING

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