A role for collagen in the pathogenesis of muscular dystrophy?

@article{Duance1980ARF,
  title={A role for collagen in the pathogenesis of muscular dystrophy?},
  author={Victor C. Duance and Heather Stephens and Matthew C Dunn and Allen J. Bailey and Victor Dubowitz},
  journal={Nature},
  year={1980},
  volume={284},
  pages={470-472}
}
The extensive proliferation of connective tissue in muscular dystrophy caused Duchenne1 to term it ‘paralysie myosclerosique’. Surprisingly, there has been little interest in the pathogenesis of this marked fibrosis or of the fat replacement in dystrophic muscle. The fibrosis has generally been considered secondary, with various hypotheses2 to explain the fundamental cause of muscular dystrophy. Several authors have commented on the increased endomysial stroma early in the disease before any… CONTINUE READING

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