A role for cingulate pioneering axons in the development of the corpus callosum

@article{Rash2001ARF,
  title={A role for cingulate pioneering axons in the development of the corpus callosum},
  author={Brian G. Rash and Linda J. Richards},
  journal={Journal of Comparative Neurology},
  year={2001},
  volume={434}
}
  • B. Rash, L. Richards
  • Published 28 May 2001
  • Biology, Medicine
  • Journal of Comparative Neurology
In many vertebrate and invertebrate systems, pioneering axons play a crucial role in establishing large axon tracts. Previous studies have addressed whether the first axons to cross the midline to from the corpus callosum arise from neurons in either the cingulate cortex (Koester and O'Leary [ 1994 ] J. Neurosci. 11:6608–6620) or the rostrolateral neocortex (Ozaki and Wahlsten [ 1998 ] J. Comp. Neurol. 400:197–206). However, these studies have not provided a consensus on which populations… 
Axonal pathfinding mechanisms at the cortical midline and in the development of the corpus callosum.
  • L. Richards
  • Biology, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2002
TLDR
Midline glial populations are important intermediate targets for commissural axons in the spinal cord and brain, including the corpus callosum, and the differential guidance of the ipsilaterally projecting perforating pathway and the contralaterally projecting corpuscallosum is addressed.
Axon Guidance Mechanisms for Establishment of Callosal Connections
TLDR
This paper describes callosal dysgenesis in humans and mice, that results from a disruption of these navigational mechanisms that are involved in the development of the callosal neurons.
Development of the perforating pathway: An ipsilaterally projecting pathway between the medial septum/diagonal band of Broca and the cingulate cortex that intersects the corpus callosum
TLDR
Findings show that ipsilaterally projecting PFP axons and contralaterally projecting callosal axons make distinct guidance decisions at the same developmental stage when they reach the corticoseptal boundary.
Two specific populations of GABAergic neurons originating from the medial and the caudal ganglionic eminences aid in proper navigation of callosal axons
TLDR
It is shown that two distinct GABAergic neuronal subpopulations converge toward the midline prior to the arrival of callosal axons, which strongly suggests that MGE‐ and CGE‐derived interneurons may guide CC axons by multiple guidance mechanisms and signaling pathways.
Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum.
TLDR
It is demonstrated that neuropilin 1 (Npn1) plays an integral role in the development of corpus callosum (CC) development, and axons from the cingulate cortex display guidance errors in Npn1(Sema-) mice, a knockin mouse line in which NPN1 is unable to bind Semas.
Imaging, anatomical, and molecular analysis of callosal formation in the developing human fetal brain.
  • T. Ren, A. Anderson, +6 authors L. Richards
  • Biology, Medicine
    The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
  • 2006
TLDR
Analysis of midline glial and commissural development in human fetal brains ranging from 13 to 20 weeks of gestation using both diffusion tensor magnetic resonance imaging and immunohistochemistry suggests that similar mechanisms and molecules required for midline commissure formation operate during both mouse and human brain development.
PlexinA1 is crucial for the midline crossing of callosal axons during corpus callosum development in BALB/cAJ mice
TLDR
Results indicate the crucial involvement of PlexinA1 in the midline crossing of callosal axons during CC development in BALB/cAJ mice.
Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion.
TLDR
This work shows that Netrin-deleted in colorectal cancer signaling acts in a fundamentally different manner, to prevent the Slit2-mediated repulsion of precrossing axons thereby allowing them to approach and cross the midline.
Segregation and Pathfinding of Callosal Axons through EphA3 Signaling
TLDR
The role of axonal segregation in the corpus callosum, mediated at least in part by EphA3, is suggested in correct pathfinding of callosal neurons.
Slit2 Guides Both Precrossing and Postcrossing Callosal Axons at the Midline In Vivo
TLDR
In the brain, unlike the spinal cord, Slit2 mediates both precrossing and postcrossing axonal guidance, and is found to channel the axons along the correct path and possibly repel them away from the midline.
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References

SHOWING 1-10 OF 36 REFERENCES
Axons of early generated neurons in cingulate cortex pioneer the corpus callosum
  • S. Koester, D. O'Leary
  • Biology, Medicine
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
It is concluded that the two major efferent pathways from cortex, the corpus callosum and the internal capsule, are pioneered by developmentally and spatially distinct populations of early generated cortical neurons.
A role for subplate neurons in the patterning of connections from thalamus to neocortex.
TLDR
A general requirement for subplate neurons throughout neocortex in the process of cortical target selection and ingrowth by thalamic axons is underscored.
Cortical Axon Guidance by the Glial Wedge during the Development of the Corpus Callosum
TLDR
This work has identified two early differentiating populations of midline glial cells that may act as intermediate guideposts for callosal axons and identified one possible candidate for this activity because both glial populations express the chemorepellent molecule slit-2, and cortical axons express theslit-2 receptors robo-1 androbo-2.
Subplate pioneers and the formation of descending connections from cerebral cortex
TLDR
It is shown that the descending axons of cortical plate neurons appear to be delayed significantly in their outgrowth, compared with those of subplate neurons.
Requirement for subplate neurons in the formation of thalamocortical connections
TLDR
It is shown that early in development the deletion of subplate neurons located beneath visual cortex prevents axons from the lateral geniculate nucleus of the thalamus from recognizing and innervating visual cortex, their normal target.
Axonal guidance during development of the great cerebral commissures: Descriptive and experimental studies, in vivo, on the role of preformed glial pathways
TLDR
During normal ontogeny of the mouse forebrain and before the arrival of the pioneer fibers of the corpus callosum at the midline, a population of primitive glial cells migrates medially (through the fused walls of the dorsal septum) from the ependymal zones of each hemisphere.
Subplate neurons pioneer the first axon pathway from the cerebral cortex.
TLDR
The existence of a similar kind of neuron in the developing mammalian telencephalon is described, raising the possibility that the early axonal scaffold formed by subplate cells may prove essential for the establishment of permanent subcortical projections.
The early formation of the corpus callosum: a light and electron microscopic study in foetal and neonatal rats
TLDR
There is no overt morphological evidence for an active role of non-neuronal cells in axon guidance in the initial formation of the corpus callosum in foetal and neonatal rats.
Immunocytochemical demonstration of early appearing astroglial structures that form boundaries and pathways along axon tracts in the fetal brain
TLDR
The compact assemblage, early appearance and location of this and the other glial structures in relation to well defined neuroanatomical landmarks or axon pathways suggest that they may transiently compartmentalize relatively large regions of the CNS and organize certain developing fiber systems by acting as guides or barriers at critical stages of ontogeny.
Interhemispheric neocortical connections of the corpus callosum in the reeler mutant mouse: A study based on anterograde and retrograde methods
The tangential organization of the callosal system of interhemispheric connections, as judged by the distribution of axon terminals as well as by the distribution of cells of origin of callosal
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