A role for chromatin remodellers in replication of damaged DNA

@inproceedings{Niimi2012ARF,
  title={A role for chromatin remodellers in replication of damaged DNA},
  author={Atsuko Niimi and Anna L Chambers and Jessica A Downs and A. R. Lehmann},
  booktitle={Nucleic acids research},
  year={2012}
}
In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure. There are two isoforms of the Remodels the Structure of Chromatin (RSC) remodelling complex in yeast. We show that deletion of RSC2 results in a dramatic reduction in the level of PCNA ubiquitination after DNA-damaging treatments, whereas no such effect was observed after deletion of… CONTINUE READING

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