A role for chloride in the hyperpolarizing effect of acetylcholine in isolated frog vestibular hair cells

@article{Holt2000ARF,
  title={A role for chloride in the hyperpolarizing effect of acetylcholine in isolated frog vestibular hair cells},
  author={J Chris Holt and Alberto Pantoja and Grace B Athas and Paul S. Guth},
  journal={Hearing Research},
  year={2000},
  volume={146},
  pages={17-27}
}
Acetylcholine (ACh) is the dominant transmitter released from inner ear efferent neurons. In frog vestibular organs, these efferent neurons synapse exclusively with type II hair cells. Hair cells isolated from the frog saccule hyperpolarize following the application of 50 microM ACh, thereby demonstrating the presence of an ACh receptor. A role for Cl(-) in the response of hair cell-bearing organs to efferent nerve activation or ACh application was suggested some years ago. Perfusion with… CONTINUE READING