A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response

@article{Masumoto2005ARF,
  title={A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response},
  author={Hiroshi Masumoto and David H. Hawke and Ryuji Kobayashi and Alain Verreault},
  journal={Nature},
  year={2005},
  volume={436},
  pages={294-298}
}
DNA breaks are extremely harmful lesions that need to be repaired efficiently throughout the genome. However, the packaging of DNA into nucleosomes is a significant barrier to DNA repair, and the mechanisms of repair in the context of chromatin are poorly understood. Here we show that lysine 56 (K56) acetylation is an abundant modification of newly synthesized histone H3 molecules that are incorporated into chromosomes during S phase. Defects in the acetylation of K56 in histone H3 result in… 

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