A role for casein kinase 2alpha in the Drosophila circadian clock.

@article{Lin2002ARF,
  title={A role for casein kinase 2alpha in the Drosophila circadian clock.},
  author={J T Lin and Valerie L. Kilman and Kevin P. Keegan and Brie E. Paddock and Myai Emery-Le and Michael Rosbash and Ravi Allada},
  journal={Nature},
  year={2002},
  volume={420 6917},
  pages={816-20}
}
Circadian clocks drive rhythmic behaviour in animals and are regulated by transcriptional feedback loops. For example, the Drosophila proteins Clock (Clk) and Cycle (Cyc) activate transcription of period (per) and timeless (tim). Per and Tim then associate, translocate to the nucleus, and repress the activity of Clk and Cyc. However, post-translational modifications are also critical to proper timing. Per and Tim undergo rhythmic changes in phosphorylation, and evidence supports roles for two… CONTINUE READING
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