A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine

@article{Bryant2008ARF,
  title={A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine},
  author={Camron D. Bryant and Melissa E. Graham and Margaret G. Distler and Michaelanne B. Munoz and Dongdong Li and Paul Vezina and Greta Sokoloff and Abraham A Palmer},
  journal={Psychopharmacology},
  year={2008},
  volume={203},
  pages={703-711}
}
We previously colocalized a quantitative trait locus (QTL) for sensitivity to the locomotor stimulant effects of methamphetamine (MA) with a QTL for expression of casein kinase 1 epsilon (Csnk1-ɛ) in the nucleus accumbens (NAc). Subsequently, we identified a single nucleotide polymorphism in CSNK1E (rs135745) that was associated with increased sensitivity to the subjective effects of d-amphetamine in healthy human subjects. Based on these results, we hypothesized that differential expression of… CONTINUE READING

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