A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation.

@article{Tatsumi2009ARF,
  title={A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation.},
  author={Ryuichi Tatsumi and Adam L Wuollet and Kuniko Tabata and Shotaro Nishimura and Shoji Tabata and Wataru Mizunoya and Yoshihide Ikeuchi and Ronald E. Allen},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={296 4},
  pages={C922-9}
}
When skeletal muscle is stretched or injured, myogenic satellite cells are activated to enter the cell cycle. This process depends on nitric oxide (NO) production by NO synthase (NOS), matrix metalloproteinase activation, release of hepatocyte growth factor (HGF) from the extracellular matrix, and presentation of HGF to the c-met receptor as demonstrated by a primary culture and in vivo assays. We now add evidence that calcium-calmodulin is involved in the satellite cell activation cascade in… CONTINUE READING

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