A role for brown adipose tissue in diet-induced thermogenesis

  title={A role for brown adipose tissue in diet-induced thermogenesis},
  author={Nancy J. Rothwell and Michael J. Stock},
Measurement of energy balance during voluntary over-eating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system and brown adipose tissue which suggest that this tissue may determine metabolic efficiency and resistance to obesity. 
A role for brown adipose tissue in diet-induced thermogenesis.
Measurement of energy balance during voluntary overeating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-inducedExpand
Brown Adipose Tissue, Diet-Induced Thermogenesis and Genetic Obesity
Brown adipose tissue is a thermogenic organ that effectively participates in the maintenance of body temperature in newborn mammals and in adult hibernating animals. The high triglyceride content ofExpand
Brown fat and the myth of diet-induced thermogenesis.
  • L. Kozak
  • Biology, Medicine
  • Cell metabolism
  • 2010
Studies in obese rats and mice lacking UCP1 indicate that diet-induced thermogenesis by BAT is unlikely, and brown adipose tissue in mice or humans maintains energy balance by burning off excess calories. Expand
Thermogenic Role of Brown Adipose Tissue and Skeletal Muscle in Humans
In adult humans brown adipose tissue has no important thermogenic role. It is true that infusion of catecholamines may increase energy expenditure by 25–30%, but this thermogenesis seems to takeExpand
Effects of adrenalectomy on energy balance, diet-induced thermogenesis and brown adipose tissue in adult cafeteria-fed rats.
Adrenalectomy prevented the development of obesity in cafeteria-fed rats by depressing food intake and energetic efficiency, and markedly increased the thermogenic activity of brown adipose tissue, and depressed insulin levels, particularly in the cafeteria group. Expand
Brown adipose tissue: thermic response increased by a single low protein, high carbohydrate meal.
The weight of interscapular brown fat in the rat and its rate of respiration increased in response to a single meal. These data suggest that brown adipose tissue plays a role in the thermic effect ofExpand
Dopaminergic mechanisms in diet-induced thermogenesis and brown adipose tissue metabolism.
Hyperphagic, cafeteria-fed rats exhibited higher rates of resting oxygen consumption (VO2) and increased DA release and turnover in brown adipose tissue relative to control animals and Pimozide completely abolished the difference in VO2 between the two groups and DA stimulated VO2 in control and cafeteria animals. Expand
Thermogenesis in brown adipose tissue as an energy buffer. Implications for obesity.
In this study, studies with laboratory animals have provided an explanation for such large individual variations in energy requirements and have shown that brown adipose tissue buffers changes in food intake. Expand
Thermogenesis in normal rabbits and rats: no role for brown adipose tissue?
1. The occurrence of dietary and cold‐induced thermogenesis in young rabbits was unaffected by noradrenaline or propranolol, and it is concluded that the brown adipose tissue, although detectableExpand
Neural regulation of thermogenesis
Chronic overfeeding can produce large increases in metabolic rate (diet-induced thermogenesis, DIT) which tend to stabilize body weight and central mechanisms controlling DIT appear to be closely related to those involved in the control of food intake. Expand


Energy balance in reversible obesity
Various methods of producing reversible obesity in animals are reviewed, and include high-fat feeding, insulin-induced hyperphagia, force-feeding and feeding a mixed and varied diet (the cafeteriaExpand
Time-dependent responses of brown fat in cold-exposed rats.
Time-dependent changes in metabolism, mass, composition, and total heat production of brown adipose tissue in cold-exposed rats
Reduced thermogenesis in obesity
It is reported here that obese adults with a family history of obesity have a reduced metabolic response to noradrenaline infusion compared with thin adults and the reduced non-shivering thermogenesis appears to be constitutional and not a secondary consequence of obesity. Expand
Metabolic Origins of Thermogenesis induced by Diet
The possible origins of dietary induced thermogenesis are discussed and the role of energetically non-conservative metabolic pathways in energy homeostasis is described. Expand
Thermoregulation in genetically obese rodents: the relationship to metabolic efficiency
The nutritional studies support the metabolic rate measurements in showing that the high gross efficiency of the ob/ob mouse is attributable to a reduced energy expenditure on thermoregulatory thermogenesis, and it is suggested that the primary reason for this reduction is that the ob-ob mouse may have a lower hypothalamic ‘set-point’ for body temperature. Expand
The energy cost of fat and protein deposition in the rat.
It is concluded with confidence that the energy costs of depositing 1 g of protein or fat are almost identical at 53 kJ ME/g, which agrees extremely closely with recent, more tentative, estimates based on assumptions as to maintenance requirement. Expand
A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding.
Atractyloside-insensitive binding of purine nucleotides is reduced in brown adipose tissue mitochondria of the obese ( ob ob ) mouse and it is suggested that the impaired thermogenesis of the ob ob mouse is due to a defect in this pathway in the mitochondria. Expand
Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline.
Flow to heart and to muscles involved in respiratory movements was two to five times greater during calorigenesis and flow to most other tissues and organs increased or decreased by less than 40%. Expand
Dietary obesity in adult rats: Similarities to hypothalamic and human obesity syndromes
The dietary obese rats did not normally defend their excessive weights since they were less willing to eat quinine diets, worked less for food, failed to increase their activity when deprived, and regained their weight at a slower rate following a fast than did controls. Expand
Stimulation of the sympathetic nervous system during sucrose feeding
Increased sympathetic activity in the hearts of overfed animals after 3d of sucrose supplementation may contribute to the enhanced thermogenesis associated with overfeeding. Expand