A role for bone morphogenetic proteins in the induction of cardiac myogenesis.

@article{Schultheiss1997ARF,
  title={A role for bone morphogenetic proteins in the induction of cardiac myogenesis.},
  author={Thomas M. Schultheiss and John B.E. Burch and Andrew B. Lassar},
  journal={Genes & development},
  year={1997},
  volume={11 4},
  pages={451-62}
}
Little is known about the molecular mechanisms that govern heart specification in vertebrates. Here we demonstrate that bone morphogenetic protein (BMP) signaling plays a central role in the induction of cardiac myogenesis in the chick embryo. At the time when chick precardiac cells become committed to the cardiac muscle lineage, they are in contact with tissues expressing BMP-2, BMP-4, and BMP-7. Application of BMP-2-soaked beads in vivo elicits ectopic expression of the cardiac transcription… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
196 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 196 extracted citations

Similar Papers

Loading similar papers…