A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase.

@article{Nielsen2009ARF,
  title={A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase.},
  author={Claus Henrik Nielsen and Thomas Heiberg Brix and Robert Leslie and Laszlo Heged{\"u}s},
  journal={Clinical immunology},
  year={2009},
  volume={133 2},
  pages={218-27}
}
The role of thyroid peroxidase (TPO) antibodies (TPOAbs) in the pathogenesis of autoimmune thyroid disease is unclear. We selected sera with a high concentration of TPOAbs from eleven patients with Hashimoto's thyroiditis (HT), ten healthy monozygotic co-twins to HT patients, and twelve healthy individuals with no familiar disposition to AITD, and mixed each serum with normal mononuclear cells (MNCs). Following challenge with TPO, the MNCs' production of the pro-inflammatory cytokines TNF-alpha… CONTINUE READING
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