A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity.

  title={A role for atypical cadherin Celsr3 in hippocampal maturation and connectivity.},
  author={Jia Xi Feng and Ying Xu and Meizhi Wang and Yiwen Ruan and Kwok-fai So and Fadel Tissir and Andr{\'e} Goffinet and Libing Zhou},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={32 40},
Atypical cadherin Celsr3, a regulator of planar cell polarity, is critical for the development of the axonal blueprint. We previously showed that expression of Celsr3 is necessary to establish forebrain connections such as the anterior commissure and thalamocortical and corticospinal tracts. The requirement for Celsr3 during hippocampal wiring and its action in the hippocampus remain largely unexplored. Here, we compared the connectivity and maturation of the hippocampal formation in Celsr3… CONTINUE READING
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