A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics.

@article{Raghavan2003ARF,
  title={A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics.},
  author={Srikala Raghavan and Alec Vaezi and Elaine Fuchs},
  journal={Developmental cell},
  year={2003},
  volume={5 3},
  pages={415-27}
}
alphabeta1 integrins have been implicated in the survival, spreading, and migration of cells and tissues. To explore the underlying biology, we identified conditions where primary beta1 null keratinocytes adhere, proliferate, and display robust alphavbeta6 integrin-induced, peripheral focal contacts associated with elaborate stress fibers. Mechanistically, this appears to be due to reduced FAK and Src and elevated RhoA and Rock activities. Visualization on a genetic background of GFPactin shows… CONTINUE READING