A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

@article{Santana2003ARF,
  title={A role for advanced glycation end products in diminished bone healing in type 1 diabetes.},
  author={Ronaldo B Santana and Lei Xu and Hermik Babakhanlou Chase and Salomon Amar and Dana T Graves and Philip C Trackman},
  journal={Diabetes},
  year={2003},
  volume={52 6},
  pages={1502-10}
}
The effect of type 1 diabetes on bone healing and bone formation in standardized craniotomy defects created in BALB/cByJ mice was determined. The hypothesis that advanced glycation end products (AGEs) contribute to diminished bone healing in diabetes was evaluated by assessing for the presence of the receptor for advanced glycation end products (RAGE) by immunohistochemistry in healing craniotomy defects in diabetic animals. The effect of local application of a known RAGE protein ligand, N… CONTINUE READING

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