A role for a melanosome transport signal in accessing the MHC class II presentation pathway and in eliciting CD4+ T cell responses.

@article{Wang1999ARF,
  title={A role for a melanosome transport signal in accessing the MHC class II presentation pathway and in eliciting CD4+ T cell responses.},
  author={S Wang and S Bartido and G Yang and J Qin and Y Moroi and K S Panageas and J J Lewis and Alan N. Houghton},
  journal={Journal of immunology},
  year={1999},
  volume={163 11},
  pages={5820-6}
}
  • S Wang, S Bartido, +5 authors Alan N. Houghton
  • Published 1999 in Journal of immunology
Melanosomal membrane proteins are frequently recognized by the immune system of patients with melanoma and vitiligo. Melanosomal glycoproteins are transported to melanosomes by a dileucine-based melanosomal transport signal (MTS). To investigate whether this sorting signal could be involved in presentation of melanosome membrane proteins to the immune system, we devised a fusion construct containing the MTS from the mouse brown locus product gp75/tyrosinase-related protein-1 and full-length OVA… CONTINUE READING