A role for a complex between activated G protein-coupled receptors in yeast cellular mating.

@article{Shi2007ARF,
  title={A role for a complex between activated G protein-coupled receptors in yeast cellular mating.},
  author={Chunhua Shi and Susan G W Kaminskyj and Sarah Caldwell and Michele C. Loewen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 13},
  pages={5395-400}
}
Cell-cell fusion is a fundamental process that facilitates a wide variety of biological events in organisms ranging from yeast to humans. However, relatively little is actually understood with respect to fusion mechanisms. In the model organism Saccharomyces cerevisiae, mating of opposite-type cells is triggered by pheromone activation of the G protein-coupled receptors, alpha-factor receptor (Ste2p) and a-factor receptor (Ste3p), leading to mitogen-activated protein kinase signaling, growth… CONTINUE READING