A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins.

@article{Chiang1989ARF,
  title={A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins.},
  author={Hui Ling Chiang and Stanley R. Terlecky and Catherine Plant and J. Fred Dice},
  journal={Science},
  year={1989},
  volume={246 4928},
  pages={382-5}
}
A 73-kilodalton (kD) intracellular protein was found to bind to peptide regions that target intracellular proteins for lysosomal degradation in response to serum withdrawal. This protein cross-reacted with a monoclonal antibody raised to a member of the 70-kD heat shock protein (hsp70) family, and sequences of two internal peptides of the 73-kD protein confirm that it is a member of this family. In response to serum withdrawal, the intracellular concentration of the 73-kD protein increased… CONTINUE READING
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