A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.

@article{Pulimeno2011ARF,
  title={A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.},
  author={Pamela Pulimeno and Serge Paschoud and Sandra Citi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 19},
  pages={16743-50}
}
Paracingulin is a 160-kDa protein localized in the cytoplasmic region of epithelial tight and adherens junctions, where it regulates RhoA and Rac1 activities by interacting with guanine nucleotide exchange factors. Here, we investigate the molecular mechanisms that control the recruitment of paracingulin to cell-cell junctions. We show that paracingulin forms a complex with the tight junction protein ZO-1, and the globular head domain of paracingulin interacts directly with ZO-1 through an N… CONTINUE READING
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inTight Junctions (Gonzalez-Mariscal, L., ed

  • L. Guillemot, S. andCiti
  • 2006

Paracingulin Interacts with ZO-1 and PLEKHA7 16750 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • A. S. Fanning, T. Y. Ma, J. M. Anderson
  • FASEB J. 16,
  • 2002

inTight Junctions (Cereijido,M

  • S. Citi
  • 2nd Ed.,
  • 2001

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