A role for WNT proteins in induction of dermomyotome.

  title={A role for WNT proteins in induction of dermomyotome.},
  author={C M Fan and Catherine S N Lee and Marc Tessier-Lavigne},
  journal={Developmental biology},
  volume={191 1},
Dorsoventral patterning of somites into sclerotome and dermomyotome involves antagonistic actions of ventralizing and dorsalizing signals originating from tissues surrounding the somites. The notochord and the floor plate of the neural tube provide a ventralizing signal(s) directing sclerotome development, whereas the surface ectoderm and dorsal neural tube provide a dorsalizing signal(s) directing dermomyotome development. Evidence has been provided that Sonic Hedgehog mediates the… CONTINUE READING