A role for TGF-beta in oligodendrocyte differentiation

@article{Mckinnon1993ARF,
  title={A role for TGF-beta in oligodendrocyte differentiation},
  author={Randall D Mckinnon and Graziella Piras and Jyun Ida and Monique Dubois-Dalcq},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={121},
  pages={1397 - 1407}
}
Oligodendrocyte-type-2 astrocyte (O-2A) glial progenitor cells undergo a limited number of mitotic divisions in response to PDGF before differentiating into oligodendrocytes, the myelin-forming cell of the CNS. We examined the mechanism limiting O-2A proliferation, and demonstrate that these cells secrete an inhibitor of cell proliferation that can be neutralized with antibodies to TGF-beta. O-2A cells also secrete an inhibitory activity that cannot be neutralized with TGF-beta antibodies. O-2A… CONTINUE READING

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