A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.

  title={A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.},
  author={S. W. Chan and C. J. Lim and K. Guo and C. P. Ng and I. Lee and W. Hunziker and Qi Zeng and W. Hong},
  journal={Cancer research},
  volume={68 8},
  • S. W. Chan, C. J. Lim, +5 authors W. Hong
  • Published 2008
  • Biology, Medicine
  • Cancer research
  • TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role in the migration, invasion, and tumorigenesis of breast cancer cells. TAZ is conspicuously expressed in human breast cancer cell lines in which its expression levels generally correlate with the invasiveness of cancer cells. Overexpression of TAZ in low-expressing MCF10A cells causes morphologic changes characteristic of cell… CONTINUE READING
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