A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.

@article{Chan2008ARF,
  title={A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.},
  author={Siew Wee Chan and Chun Jye Lim and Ke Guo and Chee Peng Ng and Ian Lee and Walter Hunziker and Qi Zeng and Wanjin Hong},
  journal={Cancer research},
  year={2008},
  volume={68 8},
  pages={2592-8}
}
TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, modulates mesenchymal stem cell differentiation. We now show that TAZ plays a critical role in the migration, invasion, and tumorigenesis of breast cancer cells. TAZ is conspicuously expressed in human breast cancer cell lines in which its expression levels generally correlate with the invasiveness of cancer cells. Overexpression of TAZ in low-expressing MCF10A cells causes morphologic changes characteristic of cell… CONTINUE READING
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