A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing.

@article{Trapp2008ARF,
  title={A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing.},
  author={Stefan Trapp and M Isabel Aller and William Wisden and Alexander V. Gourine},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 35},
  pages={8844-50}
}
Acid-sensitive K+ channels of the tandem P-domain K+-channel family (TASK-1 and TASK-3) have been implicated in peripheral and central respiratory chemosensitivity; however, because of the lack of decisive pharmacological agents, the final proof of the role of the TASK channel in the chemosensory control of breathing has been missing. In the mouse, TASK-1 and TASK-3 channels are dispensable for central respiratory chemosensitivity (Mulkey et al., 2007). Here, we have used knock-out animals to… CONTINUE READING
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