A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.

Abstract

Mice heterozygous for the tight-skin (Tsk) mutation develop skin fibrosis. Previous studies have implicated a role for the immune system and, specifically, CD4(+) T cells, in the etiology of skin fibrosis in Tsk/+ mice. We have recently shown that the administration of neutralizing anti-IL-4 antibodies to Tsk/+ mice prevented the development of skin… (More)

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Cite this paper

@article{Ong1999ARF, title={A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.}, author={C. J. Ong and Shannon Ip and S. J. Teh and Catherine C L Wong and Frank Robert Jirik and M. J. Grusby and H S Teh}, journal={Cellular immunology}, year={1999}, volume={196 1}, pages={60-8} }