A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve.

@article{Wallace1999ARF,
  title={A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve.},
  author={Valerie A Wallace and Martin C. Raff},
  journal={Development},
  year={1999},
  volume={126 13},
  pages={2901-9}
}
Retinal ganglion cell (RGC) axons have been shown to stimulate the proliferation of astrocytes in the developing rodent optic nerve, but the signals that mediate this effect have not been identified. The following findings suggest that Sonic hedgehog (Shh) is one of the signals. (1) RGCs express both Shh mRNA and protein, whereas the optic nerve contains the protein but not the mRNA. (2) Astrocytes and their precursors in the developing optic nerve express the Hedgehog (Hh) receptor gene… CONTINUE READING

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  • R. J. S. Wechsler-Reya, P. M.
  • NEURONAL
  • 1999

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