A role for SUMO modification in transcriptional repression and activation.

@article{Lyst2007ARF,
  title={A role for SUMO modification in transcriptional repression and activation.},
  author={Matthew James Lyst and Irina Stancheva},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 6},
  pages={
          1389-92
        }
}
Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription. Conjugation of SUMO to target proteins has generally been considered as a repressive modification. However, there are now a growing number of examples where SUMOylation has been shown to activate transcription. Here, we discuss whether there is something intrinsically repressive about SUMOylation… CONTINUE READING

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