A role for Rho in receptor- and G protein-stimulated phospholipase C Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B

@article{Schmidt1996ARF,
  title={A role for Rho in receptor- and G protein-stimulated phospholipase C Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B},
  author={Martina Schmidt and Christine Bienek and Ulrich R{\"u}menapp and Chunyi Zhang and Gerd L{\"u}mmen and Karl Heinz Jakobs and Ingo Just and Klaus Aktories and Michael Moos and Christoph von Eichel-Streiber},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1996},
  volume={354},
  pages={87-94}
}
Receptors coupled to heterotrimeric guanine nucleotide-binding proteins (G proteins) activate phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-hydrolyzing phospholipase C (PLC) enzymes by activated α or free βγ subunits of the relevant G proteins. To study whether low molecular weight G proteins of the Rho family are involved in receptor signalling to PLC, we examined the effect of Clostridium difficile toxin B, which glucosylates and thereby inactivates Rho proteins, on the regulation of… CONTINUE READING
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Phospholipid signaling

  • Eichel-Streiber C von, U Havperath, U Bosse, U Hadding
  • 1995

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