A role for Rab10 in von Willebrand factor release discovered by an AP-1 interactor screen in C. elegans.

Abstract

BACKGROUND Endothelial von Willebrand factor (VWF) mediates platelet adhesion and acts as a protective chaperone to clotting factor VIII. Rapid release of highly multimerized VWF is particularly effective in promoting hemostasis. To produce this protein, an elaborate biogenesis is required, culminating at the trans-Golgi network (TGN) in storage within… (More)
DOI: 10.1111/j.1538-7836.2010.04138.x

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