A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Abstract

PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase) catalyses the formation and degradation of fructose 2,6-P(2) (fructose 2,6-bisphosphate) and is also a glucokinase-binding protein. The role of fructose 2,6-P(2) in regulating glucose metabolism and insulin secretion in pancreatic beta-cells is unresolved. We down-regulated the endogenous… (More)

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@article{Arden2008ARF, title={A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.}, author={Catherine Arden and Laura J. Hampson and Guo Ce Huang and James A. M. Shaw and Ali Aldibbiat and Graham Holliman and Derek M D Manas and Salmaan Ahmed Khan and Alex J. Lange and Loranne Agius}, journal={The Biochemical journal}, year={2008}, volume={411 1}, pages={41-51} }