A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.

@article{Zhang2003ARF,
  title={A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.},
  author={Lin Zhang and Wei Wang and Yasuhito Hayashi and James V. Jester and David E. Birk and Min Gao and Chia-Yang Liu and Winston W. Y. Kao and Michael Karin and Ying Xia},
  journal={The EMBO journal},
  year={2003},
  volume={22 17},
  pages={4443-54}
}
MEKK1-deficient mice show an eye open at birth phenotype caused by impairment in embryonic eyelid closure. MEK kinase 1 (MEKK1) is highly expressed in the growing tip of the eyelid epithelium, which displays loose cell-cell contacts and prominent F-actin fibers in wild-type mice, but compact cell contacts, lack of polymerized actin and a concomitant impairment in c-Jun N-terminal phosphorylation in MEKK1-deficient mice. In cultured keratinocytes, MEKK1 is essential for JNK activation by TGF… CONTINUE READING

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