A role for LYNX2 in anxiety-related behavior.

  title={A role for LYNX2 in anxiety-related behavior.},
  author={Ayse B Tekinay and Yi Nong and Julie M Miwa and Ivo Lieberam and Ines Iba{\~n}ez-Tallon and Paul Greengard and Nathaniel Heintz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 11},
Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular mechanisms contributing to the functions of these structures are poorly understood. Here we report that deletion of Lynx2, a mammalian prototoxin gene that is expressed at high levels in anxiety associated brain areas, results in elevated anxiety-like behaviors. We show that… CONTINUE READING

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