A role for Kaiso–p120ctn complexes in cancer?

@article{Roy2005ARF,
  title={A role for Kaiso–p120ctn complexes in cancer?},
  author={Frans van Roy and Pierre D. McCrea},
  journal={Nature Reviews Cancer},
  year={2005},
  volume={5},
  pages={956-964}
}
Kaiso belongs to the zinc finger and broad-complex, tramtrack and bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein family that has been implicated in tumorigenesis. Kaiso was first discovered in a complex with the armadillo-domain protein p120ctn and later shown to function as a transcriptional repressor. As p120ctn seems to relieve Kaiso-mediated repression, its altered intracellular localization in some cancer cells might result in aberrant Kaiso nuclear activity. Intriguingly, Kaiso's… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

Proceedings of the National Academy of Sciences of the United States of America • 2014
View 3 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Essential role of non-canonical Wnt signalling in neural crest migration

J. De Calisto, C. Araya, L. Marchant, C. F. Riaz, R. Mayor
Development 132, • 2005

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

T Maeda
Nature 433, • 2005

The p120 family of cell adhesion molecules.

European journal of cell biology • 2005

Similar Papers

Loading similar papers…