A role for Kaiso–p120ctn complexes in cancer?

  title={A role for Kaiso–p120ctn complexes in cancer?},
  author={Frans van Roy and Pierre D. McCrea},
  journal={Nature Reviews Cancer},
Kaiso belongs to the zinc finger and broad-complex, tramtrack and bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein family that has been implicated in tumorigenesis. Kaiso was first discovered in a complex with the armadillo-domain protein p120ctn and later shown to function as a transcriptional repressor. As p120ctn seems to relieve Kaiso-mediated repression, its altered intracellular localization in some cancer cells might result in aberrant Kaiso nuclear activity. Intriguingly, Kaiso's… CONTINUE READING


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