A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells.

@article{Lin2000ARF,
  title={A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells.},
  author={Clement Yi Qun Lin and Jarnail Singh and Kazuko Murata and Yoko Itahana and Simona Parrinello and Shile Liang and Cheryl E. Gillett and Judith Campisi and Pierre Yves Desprez},
  journal={Cancer research},
  year={2000},
  volume={60 5},
  pages={
          1332-40
        }
}
The helix-loop-helix protein Id-1 inhibits the activity of basic helix-loop-helix transcription factors, and is an important regulator of cell growth and tissue-specific differentiation. We have shown (P. Y. Desprez et al., Mol. Cell. Biol., 18: 4577-4588, 1998) that ectopic expression of Id-1 inhibits differentiation and stimulates the proliferation and invasiveness of mouse mammary epithelial cells, and that there is a correlation between the levels of Id-1 protein and the aggressiveness of… CONTINUE READING

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