A role for IL-27 in early regulation of Th1 differentiation.

@article{Owaki2005ARF,
  title={A role for IL-27 in early regulation of Th1 differentiation.},
  author={Toshiyuki Owaki and Masayuki Asakawa and Noriko Morishima and Kikumi Hata and Fumio Fukai and Masanori Matsui and Junichiro Mizuguchi and Takayuki Yoshimoto},
  journal={Journal of immunology},
  year={2005},
  volume={175 4},
  pages={
          2191-200
        }
}
IL-27 is a novel IL-6/IL-12 family cytokine that is considered to play a role in Th1 differentiation, whereas the exact role of IL-27 in Th1 differentiation and its molecular mechanism remain unclear. In this study we demonstrate a role for IL-27 in the early regulation of Th1 differentiation and its possible molecular mechanism. The ability of IL-27 to induce Th1 differentiation was most prominent under Th1-polarizing conditions, but without IL-12 in a STAT4- and IFN-gamma-independent manner… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 60 CITATIONS, ESTIMATED 50% COVERAGE

122 Citations

051015'08'11'14'17
Citations per Year
Semantic Scholar estimates that this publication has 122 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…