A role for IL-27 in early regulation of Th1 differentiation.

@article{Owaki2005ARF,
  title={A role for IL-27 in early regulation of Th1 differentiation.},
  author={Toshiyuki Owaki and Masayuki Asakawa and Noriko Morishima and Kikumi Hata and Fumio Fukai and Masanori Matsui and Junichiro Mizuguchi and Takayuki Yoshimoto},
  journal={Journal of immunology},
  year={2005},
  volume={175 4},
  pages={
          2191-200
        }
}
IL-27 is a novel IL-6/IL-12 family cytokine that is considered to play a role in Th1 differentiation, whereas the exact role of IL-27 in Th1 differentiation and its molecular mechanism remain unclear. In this study we demonstrate a role for IL-27 in the early regulation of Th1 differentiation and its possible molecular mechanism. The ability of IL-27 to induce Th1 differentiation was most prominent under Th1-polarizing conditions, but without IL-12 in a STAT4- and IFN-gamma-independent manner… CONTINUE READING
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